Progressive Retinal Atrophy (PRA-GUCY2D)

Retinal diseases in dogs can be classified as progressive, stationary or developmental. Progressive retinal atrophy (PRA) is a group of degenerative diseases, that affect eyes and lead to blindness in dogs. PRA is a non-painful condition in which photoreceptor cells deteriorate over time. The disease starts with a decreased ability to see well at night. There are two main forms of disease: an early onset form, which was first detected in puppies 2-3 months old and late onset form, that was diagnosed in adult dogs, 3-9 years old. Clinical signs of affected dogs may include: dilated pupils, abnormally reflective eyes when a light shines on them, cataract formation in eyes, reluctance to enter a dark room. The disease is inherited in autosomal recessive manner.

Inheritance: autosomal recessive

Mutation: GUCY2D gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.