Progressive Retinal Atrophy (PRA-CNGA1)

Progressive retinal atrophy (PRA) is an inherited disease that occurs in many breeds of dogs and is reflected in various clinically indistinguishable forms. Progressive rod and cone degeneration in retina leads to progressive vision loss, which can end with total blindness. A form of PRA called CNGA1-PRA was described in Shetland sheepdog. On average clinical signs become apparent at 5 years of age (2-11 years). The breed suffers from an additional form of retinal degeneration (SPR), that progresses more slowly and does not cause such obvious visual impairment as does PRA. Unfortunately, there is no genetic test for SPR yet.

Inheritance: autosomal recessive

Mutation: CNGA1 gene

Genetic test: The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.