Prekallikrein Deficiency

Prekallikrein deficiency is an uncommon autosomal recessive disorder. It is a hemostatic disease characterized by deficiency of coagulation factor prekallikrein (PK). PK is a blood protein that is involved in the blood clotting process, so affected dogs experience prolonged activated partial thromboplastin time. The disease is usually asymptomatic with no signs of hematostatic defect in the absence of other blood clotting factor deficiencies, which makes it harder to discover.

Inheritance: autosomal recessive

Mutation: KLKB1 gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.