Osteogenesis Imperfecta (OI) - Beagle

Osteogenesis imperfecta is an autosomal dominant disease caused by a mutation in the COLA2 gene, which encodes collagen. Mutations altering the sequence can lead to disruptions of the collagen structure, which can lead to abnormally brittle bones that fracture very easily. The disease can be found in several dog breeds. The affected newborn puppies are exposed to fractures affecting almost every long bone right after birth and often have to be euthanized due to severe pain.

Inheritance: autosomal dominant

Mutation: COL1A2 gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.