Maxillary Canine-Tooth Mesioversion (MCM)

Maxillary canine-tooth mesioversion (MCM) is a genetically complex dental anomaly observed in the Shetland Sheepdog breed characterized by forward displacement of one or both upper canines toward the snout. The disease may cause traumatic abnormal occlusion, ulceration of the upper lip, and/or periodontal disease and may require extraction or orthodontic repositioning. It is rarely observed outside of the Shetland Sheepdog, a breed that also has a high prevalence of hypodontia (one or more congenitally missing teeth). Genetic variants associated with MCM where also associated with body hight and weight. Homozygous dogs with mutation in FTSJ3 gene on chromosome 9 have a high risk for MCM and have smaller body size.

Inheritance: autosomal dominant

Mutation: FTSJ3 gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy cats. Testing can be done at any age