Congenital Ichthyosis - Great Dane

Hereditary ichthyoses represent a heterogeneous group of skin cornification disorders characterized by hyperkeratosis and blistering or scaling of different severity levels. In Great Dane the disease is characterized by severe hyperkeratosis with a formation of strongly wrinkled, thickening and scaling skin, especially in the region of eyes and nose. The symptoms become evident right after birth and thus include dry and scaling skin, untidy appearance and a swollen skin, which all can lead to secondary infections. Affected dogs are usually euthanized at an early age due to poor prognosis. The disease is inherited in autosomal recessive manner.

Inheritance: autosomal recessive

Mutation: SLC27A4 gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.