Hyposegmentation of Granulocytes (HG)

Hyposegmentation of granulocytes (HG) is a benign condition characterized by lack of granulocyte nuclear segmentation. The condition is common in Australian Shepherds and in the past was thought to represent the human homologue of Pelger-Huet Anomaly (PHA), which would result in restrictions on the breeding of affected dogs. Recent study provides evidence that HG in Australian Shepherd Dogs is an autosomal recessive trait without major negative consequences for health. Approximately 15% of dogs are homozygous for the causative mutation. The genetic test can be used to confirm the cause of granulocyte hyposegmentation.

Inheritance: autosomal recessive

Mutation: LMBR1L gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.