Acatalasemia

Acatalasemia is a genetic disease that affects humans and animals, including dogs. The disease is characterised by the absence or little amount of the enzyme catalase, which is responsible for breaking down hydrogen peroxide in cells. The primary function of the enzyme is to safeguard the tissues from reactive oxygen species. When there is an excess amount of hydrogen peroxide, it can harm cells and tissues by causing a process called oxidative damage. The enzyme catalase is typically present in red blood cells, mucous membranes, liver, muscles and skin. Clinical symptoms of acatalasemia in dogs may include eating or drinking difficulties, weight loss and oral bleeding which are the consequence of gum ulceration progressing to gangrene.

Inheritance: autosomal recessive

Mutation: CAT gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.