{"product_id":"diffuse-zystische-renale-dysplasie-und-hepatische-fibrose-rdhn","title":"Diffuse Cystic Renal Dysplasia and Hepatic Fibrosis (RDHN)","description":"\u003cp\u003eRenal dysplasia with hepatic fibrosis is a rare autosomal recessive disorder described in Norwich Terriers. The disease is a part of a group of ciliopathies presenting as inherited hepatorenal fibrocystic disorders. It is characterized as diffuse cystic renal disease and hepatic fibrosis. The disease is a result of functional defects in the primary cilium, which is crucial for organogenesis, and can lead to polycystic kidneys, congenital developmental syndrome and progressive single organ dysfunction. The renal cysts are located in the straight portion of the proximal tubule and thin descending and ascending limbs of Henle's loop. The disease causes clinical symptoms later in the dog's life.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e INPP5E gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54114525315395,"sku":"2700312","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_e667767e-6990-416e-8153-ed3c5609d73a.jpg?v=1769456748","url":"https:\/\/shop.feragen.at\/en\/products\/diffuse-zystische-renale-dysplasie-und-hepatische-fibrose-rdhn","provider":"FERAGEN Shop","version":"1.0","type":"link"}