{"product_id":"d-lokus-d2","title":"D-Locus (d2)","description":"\u003cp\u003eD-Locus is responsible for coat colour dilution. Known mutations of the MLPH gene (melanophilin) are responsible for most cases of diluted colours. MLPH gene encodes a protein melanophilin, a key component in the hair and skin pigment formation. A mutation in the gene causes the improper distribution of melanosomes and coat colour dilution. It has an effect on the formation of black eumelanin as well as red-yellow pheomelanin, though in lesser extent. The dilution of black pigment results in blue or grey coat colour, and dilution of brown pigment results light brown or isabella. D-Locus is not responsible only for coat pigment dilution but also dilutes pigment of the nose, pads and eyes.\u003c\/p\u003e\u003cp\u003eIn our laboratory, we test 3 different alleles in the MLPH gene responsible for coat colour dilution:\u003c\/p\u003e\u003cul\u003e\u003cli\u003e\u003cp\u003eallele d1: is responsible for coat colour dilution in many dog breeds\u003c\/p\u003e\u003c\/li\u003e\u003cli\u003e\u003cp\u003eallele d2: is present in Chow-Chow, Sloughi, Thai Ridgeback and French Bulldog\u003c\/p\u003e\u003c\/li\u003e\u003cli\u003e\u003cp\u003eallele d3: is present in Chihuahua, Mudi, Pumi, Italian Greyhound, Pekingese, Shetland Sheepdog, Shih Tzu, Tibetan Mastiff and Yorkshire Terrier.\u003c\/p\u003e\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eIn some dog breeds, several different mutations can occur at the same time. The combination of two mutations (d1\/d2 or d1\/d3) also leads to a diluted colour of the coat.\u003c\/p\u003e\u003ctable style=\"min-width: 50px;\"\u003e\u003ccolgroup\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003c\/colgroup\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eGenotype\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eD\/D:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog carries two copies of the dominant D allele and expresses normal undiluted coat colour; the dog will always transfer one copy of D allele to the offspring; all offspring will express normal undiluted coat colour.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eD\/d*(d1 or d2 or d3):\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog carries one copy of the dominant D allele and one copy of the recessive d allele; the dog is heterozygote\/carrier of d allele for colour dilution and expresses normal undiluted coat colour; the offspring will have 50% possibility to inherit D allele and 50% possibility to inherit d allele.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003ed*\/d*(d1 or d2 or d3):\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog carries two copies of the recessive d allele and expresses diluted coat colour; the dog will always transfer a copy of d allele to the offspring.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003c\/tbody\u003e\u003c\/table\u003e\u003cp\u003e\u0026nbsp;\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113832534339,"sku":"2700090","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_4ea7c19e-00bc-46eb-aed0-396b5a51bc6e.jpg?v=1769440688","url":"https:\/\/shop.feragen.at\/en\/products\/d-lokus-d2","provider":"FERAGEN Shop","version":"1.0","type":"link"}