{"title":"Individuelle Einzelanalysen","description":"\u003cp style=\"text-align: center;\"\u003e\u003ca style=\"display: inline-block; padding: 14px 28px; background: #0077b5; color: #ffffff; font-weight: bold; font-size: 16px; line-height: 1; border-radius: 999px; text-decoration: none;\" href=\"https:\/\/shop.feragen.at\/collections\/alle-analysen\"\u003e Alle Analysen anzeigen \u003c\/a\u003e\u003c\/p\u003e","products":[{"product_id":"a-lokus","title":"A-Locus","description":"\u003cp\u003eAgouti signal peptide (\u003cem\u003eASIP\u003c\/em\u003e) or A-Locus is responsible for many different colour patterns in dogs. Specific A-Locus allele products can interact with functional MC1R and thus interfere with production of black melanin. Dogs have four different\u0026nbsp;\u003cem\u003eASIP\u003c\/em\u003e\u0026nbsp;gene alleles with following dominance hierarchy: A\u003csup\u003ey\u003c\/sup\u003e\u0026nbsp;\u0026gt; a\u003csup\u003ew\u003c\/sup\u003e\u0026nbsp;\u0026gt; a\u003csup\u003et\u003c\/sup\u003e\u0026nbsp;\u0026gt; a, meaning that the most dominant allele present will be expressed.\u003c\/p\u003e\u003cp\u003eGenes on A-Locus (agouti) are expressed only if a dog on K-Locus does not carry K\u003csup\u003eB\u003c\/sup\u003e\u0026nbsp;allele (combination K\u003csup\u003eB\u003c\/sup\u003e\/K\u003csup\u003eB\u003c\/sup\u003e\u0026nbsp;or K\u003csup\u003eB\u003c\/sup\u003e\/n) and\/or on E-Locus does not have e\/e combination. In dogs that are able to express A-Locus the basic colour can be additionally modified by B or D-Locus. Thus the dog with a genotype b\/b on B locus has all the pigmented areas changed from black to chocolate\/liver brown (dog that is fawn\/sable (A\u003csup\u003ey\u003c\/sup\u003e) is a livernose, while the a\u003csup\u003et\u003c\/sup\u003e\/a\u003csup\u003et\u003c\/sup\u003e\u0026nbsp;dog has chocolate-and-tan instead of black-and-tan coat colourin addition to livernose).\u003c\/p\u003e\u003cp\u003eA\u003csup\u003ey\u003c\/sup\u003e\u0026nbsp;allele is the most dominant allele and determines the fawn or sable coat colour. The dog that has both A\u003csup\u003ey\u003c\/sup\u003ealleles (homozygote A\u003csup\u003ey\u003c\/sup\u003e\/A\u003csup\u003ey\u003c\/sup\u003e) or one in a combination A\u003csup\u003ey\u003c\/sup\u003e\/a\u003csup\u003ew\u003c\/sup\u003e\u0026nbsp;or A\u003csup\u003ey\u003c\/sup\u003e\/a\u003csup\u003et\u003c\/sup\u003e\u0026nbsp;or A\u003csup\u003ey\u003c\/sup\u003e\/a will be always fawn or sable, if A locus expression is enabled by the E and K-Loci.\u003c\/p\u003e\u003cp\u003eWild type a\u003csup\u003ew\u003c\/sup\u003e\u0026nbsp;allele is responsible for switching between eumelanin and pheomelanin synthesis, causing that individual hairs have eumelanin and pheomelanin patches from base to tip. This phenotype is called agouti (wolf grey or wolf sable). Banded hairs are usually present along the dorsal area of the torso. The dog will express agouti colour when having the combination of a\u003csup\u003ew\u003c\/sup\u003e\/a\u003csup\u003ew\u003c\/sup\u003e, a\u003csup\u003ew\u003c\/sup\u003e\/a\u003csup\u003et\u003c\/sup\u003e\u0026nbsp;or a\u003csup\u003ew\u003c\/sup\u003e\/a alleles, if A-Locus expression is enabled by the E and K-Loci.\u003c\/p\u003e\u003cp\u003eAllele a\u003csup\u003et\u003c\/sup\u003e\u0026nbsp;is responsible for black-and-tan or tricolor phenotype. Black-and-tan dogs are basic black with brown pheomelanin on ventral region, legs, cheeks and as dots above the eyebrows (eg. Doberman). Tricolor dogs in addition to black and brown have white colour due to the absence of pigment in certain areas of the body (eg. Rough Collie). The amount and distribution of pheomelanin may vary between individual dogs and between breeds. A dog with two a\u003csup\u003et\u003c\/sup\u003e\u0026nbsp;alleles or one in a a\u003csup\u003et\u003c\/sup\u003e\/a combination will be black-and-tan or tricolor (if A-Locus expression is enabled by the E and K-Loci).\u003c\/p\u003e\u003cp\u003eAllele a is the least frequent allele of the A-Locus and is responsible for recessive black or bicolor phenotype. It occurs only in shepherd breeds and is the only cause of black German Shepherd and bicolor Shetland Sheepdog. Because a allele is the most recessive of A-Locus alleles the dog must have two a alleles in order to express recessive black. The offspring will always have one a allele. In the case where an animal does not have black coat colour the result of genetic test reveals whether the dog carries recessive black allele.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eTesting for A-Locus resolves which two of the four possible alleles is present. As mentioned above, the expression depends on the status of E and K-Loci.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003ctable style=\"min-width: 50px;\"\u003e\u003ccolgroup\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003c\/colgroup\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eGenotype\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eA\u003csup\u003ey\u003c\/sup\u003e\/A\u003csup\u003ey\u003c\/sup\u003e:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog carries two copies of the dominant Ay allele for fawn\/sable; the offspring will always inherit one A\u003csup\u003ey\u003c\/sup\u003e\u0026nbsp;allele.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eA\u003csup\u003ey\u003c\/sup\u003e\/a\u003csup\u003ew\u003c\/sup\u003e:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog carries one copy of A\u003csup\u003ey\u003c\/sup\u003e\u0026nbsp;allele for fawn\/sable and one copy of allele a\u003csup\u003ew\u003c\/sup\u003e\u0026nbsp;for agouti phenotype; since A\u003csup\u003ey\u003c\/sup\u003e\u0026nbsp;dominates over a\u003csup\u003ew\u003c\/sup\u003e\u0026nbsp;fawn\/sable can be expressed; the dog is heterozygote with a 50% possibility that the offspring will inherit A\u003csup\u003ey\u003c\/sup\u003e\u0026nbsp;allele and a 50% possibility that the offspring will inherit a\u003csup\u003ew\u003c\/sup\u003e\u0026nbsp;allele.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003ea\u003csup\u003ew\u003c\/sup\u003e\/a\u003csup\u003ew\u003c\/sup\u003e:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog carries two copies of the dominant a\u003csup\u003ew\u003c\/sup\u003e\u0026nbsp;allele for agouti coat colour; the offspring will always inherit one a\u003csup\u003ew\u003c\/sup\u003e\u0026nbsp;allele.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003ea\u003csup\u003ew\u003c\/sup\u003e\/a\u003csup\u003et\u003c\/sup\u003e:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog carries one copy of a\u003csup\u003ew\u003c\/sup\u003e\u0026nbsp;allele for agouti and one copy of a\u003csup\u003et\u003c\/sup\u003e\u0026nbsp;allele for black-and-tan phenotype; since a\u003csup\u003ew\u003c\/sup\u003e\u0026nbsp;dominates over a\u003csup\u003et\u003c\/sup\u003e\u0026nbsp;agouti colour can be expressed; the dog is heterozygote with a 50% possibility that the offspring will inherit a\u003csup\u003ew\u003c\/sup\u003e\u0026nbsp;allele and a 50% possibility that the offspring will inherit a\u003csup\u003et\u003c\/sup\u003e\u0026nbsp;allele.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003ea\u003csup\u003ew\u003c\/sup\u003e\/a:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog carries one copy of a\u003csup\u003ew\u003c\/sup\u003e\u0026nbsp;allele for agouti and one copy of a allele for recessive black; since a\u003csup\u003ew\u003c\/sup\u003e\u0026nbsp;dominates over a allele agouti colour can be expressed; the dog is heterozygote with a 50% possibility that the offspring will inherit a\u003csup\u003ew\u003c\/sup\u003e\u0026nbsp;allele and a 50% possibility that the offspring will inherit a allele.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003ea\u003csup\u003et\u003c\/sup\u003e\/a:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog carries one copy of a\u003csup\u003et\u003c\/sup\u003e\u0026nbsp;allele and one copy of a allele for recessive black; since a\u003csup\u003et\u003c\/sup\u003e\u0026nbsp;dominates over a, black-and-tan can be expressed; the dog is heterozygote with a 50% possibility that the offspring will inherit a\u003csup\u003et\u003c\/sup\u003e\u0026nbsp;allele and a 50% possibility that the offspring will inherit a allele.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003ea\u003csup\u003et\u003c\/sup\u003e\/a\u003csup\u003et\u003c\/sup\u003e:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog carries two copies of the a\u003csup\u003et\u003c\/sup\u003e\u0026nbsp;allele for black-and-tan coat colour; the dog is homozygote for a\u003csup\u003et\u003c\/sup\u003e\u0026nbsp;and the offspring will always inherit a\u003csup\u003et\u003c\/sup\u003e\u0026nbsp;allele.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eA\u003csup\u003ey\u003c\/sup\u003e\/a\u003csup\u003et\u003c\/sup\u003e:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog carries one copy of A\u003csup\u003ey\u003c\/sup\u003e\u0026nbsp;allele for fawn\/sable and one copy of a\u003csup\u003et\u003c\/sup\u003e\u0026nbsp;allele for black-and-tan or tricolor; since A\u003csup\u003ey\u003c\/sup\u003e\u0026nbsp;dominates over a\u003csup\u003et\u003c\/sup\u003e\u0026nbsp;fawn\/sable can be expressed; the dog is heterozygote with a 50% possibility that the offspring will inherit A\u003csup\u003ey\u003c\/sup\u003e\u0026nbsp;allele and a 50% possibility that the offspring will inherit a\u003csup\u003et\u003c\/sup\u003e\u0026nbsp;allele.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eA\u003csup\u003ey\u003c\/sup\u003e\/a:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog carries one copy of A\u003csup\u003ey\u003c\/sup\u003e\u0026nbsp;allele for fawn\/sable and one copy of a allele for recessive black; since A\u003csup\u003ey\u003c\/sup\u003e\u0026nbsp;dominates over a fawn\/sable can be expressed; the dog is heterozygote with a 50% possibility that the offspring will inherit A\u003csup\u003ey\u003c\/sup\u003e\u0026nbsp;allele and a 50% possibility that the offspring will inherit a allele.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003ea\/a:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog carries two copies of the recessive black a allele, thus the dog can express black or bicolor coat colour (depending of the breed) the dog is homozygote for a allele and the offspring will always inherit a copy of a allele.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003c\/tbody\u003e\u003c\/table\u003e\u003cp\u003e\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54110845698371,"sku":"2700009","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_e3e557b3-c505-437b-b47c-8bb455835a76.jpg?v=1769414366"},{"product_id":"akatalasamie","title":"Acatalasemia","description":"\u003cp\u003eAcatalasemia is a genetic disease that affects humans and animals, including dogs. The disease is characterised by the absence or little amount of the enzyme catalase, which is responsible for breaking down hydrogen peroxide in cells. The primary function of the enzyme is to safeguard the tissues from reactive oxygen species. When there is an excess amount of hydrogen peroxide, it can harm cells and tissues by causing a process called oxidative damage. The enzyme catalase is typically present in red blood cells, mucous membranes, liver, muscles and skin. Clinical symptoms of acatalasemia in dogs may include eating or drinking difficulties, weight loss and oral bleeding which are the consequence of gum ulceration progressing to gangrene.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e CAT gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54110846550339,"sku":"2700001","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_22b29c9a-a0b9-4408-bd57-6ab4599ac6d9.jpg?v=1769414562"},{"product_id":"achromatopsie-zapfendegeneration-cd1-amal","title":"Achromatopsia (Cone Degeneration, CD1, AMAL)","description":"\u003cp\u003eAchromatopsia is a hereditary disease characterized by the loss of cone photoreceptor function that results in day-blindness, complete color blindness and decreased central visual acuity. The clinical signs typically manifest by 8–12 weeks of age when retinal development is completed. Cones develop normally but after a time they gradually deteriorate which cause a slow loss of cones throughout the animal’s lifetime. The rod photoreceptors remain intact. However, affected dogs remain ophthalmoscopically normal. Affected dogs become increasingly photophobic when exposed to bright light. Vision in low light conditions remains normal. Please note that there are several forms of this disease in different breeds and with this genetic test cone degeneration can be explained just in a few selected breeds.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e HCRTR2 gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54110846583107,"sku":"2700002","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_e01eb022-3f9d-4140-a1c9-5731e0f17985.jpg?v=1769414571"},{"product_id":"achromatopsie-tagesblindheit-achm-deutscher-schaferhund","title":"Cone Degeneration (CD) - German Shepherd Dog","description":"\u003cp\u003eCone Degeneration or Achromatopsia (ACHM) is a congenital retinal disorder and can vary among affected dogs by severity. The disorder manifests in poor ability of the eye to distinguish between different shapes and the details of objects at a given distance, pendular nystagmus, impaired or complete colour blindness and fear of light (light sensitivity). Loss of vision under well-lit conditions with a complete loss can occur at 8-10 weeks of age. ACHM develops due to genetic defects which results in complete loss of cone function and activity of ion channel which is a key mediator in signal transduction in retinal receptors. The disease has been identified in humans but also in German Shephard and Labrador Retriever. Clinical ophthalmic examination does not necessarily confirm the ACHM, therefore a genetic test needs to be done for disease confirmation.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e CNGA3 gene\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54110846615875,"sku":"2700003","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_f068e502-4e09-445f-921e-f390927cc7d3.jpg?v=1769414579"},{"product_id":"cone-degeneration-labrador-retriever","title":"Cone Degeneration (CD) - Labrador Retriever","description":"\u003cp\u003eCone Degeneration or Achromatopsia (ACHM) is a congenital retinal disorder and can vary among affected dogs by severity. The disorder manifests in poor ability of the eye to distinguish between different shapes and details of objects at a given distance, pendular nystagmus, impaired or complete colour blindness and fear of light (light sensitivity). Loss of vision under well-lit conditions with a complete loss can occur at 8-10 weeks of age. ACHM develops due to genetic defects which results in complete loss of cone function and activity of ion channel which is a key mediator in signal transduction in retinal receptors. The disease has been identified in humans but also in German Shephard and Labrador Retriever. Clinical ophthalmic examination does not necessarily confirm the ACHM, therefore a genetic test needs to be done for disease confirmation.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e CNGA3 gene\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54111128453443,"sku":"2700004","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_d887f4c0-9251-4433-b396-94a8ed6b9ef0.jpg?v=1769427118"},{"product_id":"akrales-mutilationssyndrom-ams","title":"Acral Mutilation Syndrom (AMS)","description":"\u003cp\u003eAcral mutilation syndrome (AMS) is a neurological disease characterized by insensitivity to pain in peripheral parts of the body (limbs, fingers, toes), combined with self-mutilation. Clinical signs appear in puppies approximately four months old when they begin to lick and bite their paws. Affected dogs present an acral insensitivity to pain with, in the majority of cases, severe self-mutilations of the feet including claw loss, painless fractures, and digit amputation. The disease affects only sensory neurons as affected dogs do not exhibit signs of disorders in the autonomic nervous system, motor functions, and proprioception.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e upstream of GDNF gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers, and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54111128584515,"sku":"2700005","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_11939cc1-7078-433c-a494-bd398186cb61.jpg?v=1769427127"},{"product_id":"akutes-atemnot-syndrom-ards","title":"Acute Respiratory Distress Syndrome (ARDS)","description":"\u003cp\u003eAcute respiratory distress syndrome (ARDS) known as an incurable lung development disorder was described in young Dalmatian dogs. The main clinical symptoms are progressive tachypnoea and noisy respiration leading to a severe respiratory distress, characterized by strenuous and rapid respirations, together with cyanosis and vomiting. First clinical signs start at 5 – 10 months of age and cause death or euthanasia of the affected puppies in 1 – 6 weeks.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e ANLN gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54111128912195,"sku":"2700006","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_a86561d6-c2c7-4488-af39-5e18955a8452.jpg?v=1769427134"},{"product_id":"afibrinogenamie-afg","title":"Afibrinogenemia (AFG)","description":"\u003cp\u003eAfibrinogenemia is an inherited bleeding disorder affecting dogs. The condition is caused by complete absence of fibrinogen, a glycoprotein that helps with blood clotting. Gene mutations interfere with the fibrinogen assembly, which results in severe bleeding episodes, that can start as early as umbilical cord bleeding in the womb. Later in life dogs show signs of frequent and easy bruising of the skin, hematomas, nose and gum bleeds and in some cases internal bleeding leading to frequent dark or bloody feces. The condition can cause severe spontaneous bleeding usually as a result of trauma caused by injury or surgery. In case of bleeding in the joints, dogs appear stiff and lame. With frequent heavy bleedings, this is a potentially deadly disease and even with adequate medical treatment the life expectancy is usually shorter than a year.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e FGA gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54111135301955,"sku":"2700007","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_683de99c-32cb-42f6-afd0-768872c8d354.jpg?v=1769427143"},{"product_id":"alexander-krankheit-labrador-retriever","title":"Alexander Disease","description":"\u003cp\u003eAlexander disease is a progressive fatal neurodegenerative hereditary disorder, caused by astrocyte dysfunction. Astrocytes are specialized cells in the brain and spinal cord, which contain a specific protein called glial fibrillary acidic protein (GFAP). Mutation in GFAP gene is the most common cause of the disease. The age of affected dogs is usually less than 12 months. Clinical signs begin as incoordination, a head tilt, knuckling on limbs, issues with balance, nystagmus and an aversion to touch which later progress to ataxia, paresis in the hindlimbs and tetraparesis.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e GFAP gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54111135433027,"sku":"2700008","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_85357c14-b26f-413b-96f6-5a0a8f931c98.jpg?v=1769427151"},{"product_id":"bernard-soulier-syndrom-bss","title":"Bernard-Soulier Syndrome (BSS)","description":"\u003cp\u003eBernard – Soulier syndrome (BSS) is a rare bleeding disorder affecting platelet function found in humans and dogs (Cocker Spaniel). The main molecular feature of BSS is the lack of functional glycoprotein Ib-IX-V on the platelet surface responsible for weakened binding to von Willebrand factor and reduced ability to adhere to damaged vascular walls. In affected dogs macrothrombocytopenia is present with almost half of the platelets approximating the red blood cell volume. The most common clinical signs in dogs are frequently overlooked bleeding tendencies such as episodic and self-limiting gingival bleeding. After trauma severe haemorrhages can occur and, in such cases, the only recommended therapy is a whole blood or platelet rich plasma from a fully compatible dog. The age of onset of clinical signs is 2 to 4 years. According to studies the disease shows autosomal recessive mode of inheritance.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e GP9 gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113813463363,"sku":"2700011","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_060dee8c-e05e-4ff7-b9e6-5336dc2467dd.jpg?v=1769440041"},{"product_id":"bilaterale-taubheit-dobermann","title":"Bilateral deafness (Doberman Pinscher)","description":"\u003cp\u003eBilateral deafness is an autosomal recessive disorder, colloquially referred to as “dings”. It is characterized by early onset concurrent vestibular dysfunction and bilateral deafness. The clinical signs of affected dogs include exaggerated side-to-side head\/neck excursions, body falling, head tilt, variable loss of the righting reflex that tends to improve with age along with body ataxia, and complete hearing loss consistent with the absence of a startle reflex.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e MYO7A gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113813528899,"sku":"2700012","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_0e008658-c94e-4d0b-8436-3133ae18489b.jpg?v=1769440050"},{"product_id":"b-lokus","title":"B-Locus","description":"\u003cp\u003eGene TYRP1 (Tyrosinase related protein 1) is responsible for chocolate\/liver brown colour in dogs. This coat colour is inherited recessively. There are 4 different alleles on B-Locus: normal B allele (dominant), and three recessive alleles b\u003csup\u003ec\u003c\/sup\u003e, b\u003csup\u003es\u003c\/sup\u003e and b\u003csup\u003ed\u003c\/sup\u003e. Combination of any two recessive alleles will result in chocolate\/liver brown colour (for example two b\u003csup\u003ec\u003c\/sup\u003e alleles or one b\u003csup\u003ec \u003c\/sup\u003eand one b\u003csup\u003es\u003c\/sup\u003e allele).\u003c\/p\u003e\u003cp\u003eBecause TYRP1 gene is related to eumelanin production, it only affects dogs which have genotype E\/E or E\/e on E locus. B-Locus also affects colour of the nose, eyes and pads. Dogs with genotype e\/e produce only pheomelanin in coat but production of eumelanin in the nose, eyes and pads is not affected and therefore totally controlled by B-Locus. Depending on genotypes of E and B loci dog can have yellow coat and brown nose\/eyes (e\/e, b\/b) or chocolate coat and brown nose\/eyes (E\/e or E\/E and b\/b).\u003c\/p\u003e\u003cp\u003eTest for B-Locus is divided into three separate tests in order to find the presence of recessive alleles. Results are presented as combined results as well as results for each single allele tested.\u003c\/p\u003e\u003ctable style=\"min-width: 50px;\"\u003e\u003ccolgroup\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003c\/colgroup\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eGenotype\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eB\/B:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eDog is homozygous for normal allele; no recessive alleles for chocolate\/liver brown are present, dog will transfer dominant alleles to the entire of its offspring.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eB\/b:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eDog is heterozygous for chocolate\/liver brown when one of recessive alleles is present (for example Bc\/bc, Bs\/Bs, Bd\/Bd), brown colour is not expressed, one recessive allele can be transferred to offspring.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eb\/b:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eDog is chocolate\/liver brown (homozygous for brown colour) in eumelanin pigmented areas and carries at least two recessive alleles (identical or different), which means that dog is either homozygous for one allele (for example b\u003csup\u003ec\u003c\/sup\u003e\/b\u003csup\u003ec\u003c\/sup\u003e, B\u003csup\u003es\u003c\/sup\u003e\/B\u003csup\u003es\u003c\/sup\u003e, B\u003csup\u003ed\u003c\/sup\u003e\/B\u003csup\u003ed\u003c\/sup\u003e) or heterozygous for two alleles (for example B\u003csup\u003ec\u003c\/sup\u003e\/b\u003csup\u003ec\u003c\/sup\u003e, B\u003csup\u003es\u003c\/sup\u003e\/b\u003csup\u003es\u003c\/sup\u003e, B\u003csup\u003ed\u003c\/sup\u003e\/B\u003csup\u003ed\u003c\/sup\u003e).\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003c\/tbody\u003e\u003c\/table\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e autosomal recessive\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e TYRP1 gene\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e Test method description...\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113813725507,"sku":"2700013","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_a73b1195-ef1c-400e-864a-08d8e68f5cad.jpg?v=1769440059"},{"product_id":"b-lokus-australian-shepherd","title":"B-Locus (Australian Shepherd)","description":"\u003cp\u003eGene TYRP1 (Tyrosinase related protein 1) is responsible for chocolate\/liver brown colour in dogs. This coat colour is inherited recessively. There are 4 different variants on B-Locus in Australian Shepherds: b\u003csup\u003ec\u003c\/sup\u003e, b\u003csup\u003es\u003c\/sup\u003e, b\u003csup\u003ed\u003c\/sup\u003e and b\u003csup\u003eaus\u003c\/sup\u003e. Combination of any two recessive alleles will result in chocolate\/liver brown colour (for example two b\u003csup\u003ec\u003c\/sup\u003e alleles or one b\u003csup\u003ec\u003c\/sup\u003e and one b\u003csup\u003es\u003c\/sup\u003e allele).\u003c\/p\u003e\u003cp\u003eBecause TYRP1 gene is related to eumelanin production, it only affects dogs which have genotype E\/E or E\/e on E-Locus. B-Locus also affects colour of the nose, eyes and pads. Dogs with genotype e\/e produce only pheomelanin in coat but production of eumelanin in the nose, eyes and pads is not affected and therefore totally controlled by B-Locus. Depending on genotypes of E and B-Loci dog can have yellow coat and brown nose\/eyes (e\/e, b\/b) or chocolate coat and brown nose\/eyes (E\/e or E\/E and b\/b).\u003c\/p\u003e\u003cp\u003eTest for B-Locus in Australian Shepherds consists of four separate tests in order to find the presence of recessive alleles (b\u003csup\u003ec\u003c\/sup\u003e, b\u003csup\u003es\u003c\/sup\u003e, b\u003csup\u003ed\u003c\/sup\u003e and b\u003csup\u003eaus\u003c\/sup\u003e). Results are reported as combined results as well as results for each single allele tested.\u003c\/p\u003e\u003ctable style=\"min-width: 50px;\"\u003e\u003ccolgroup\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003c\/colgroup\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eGenotype\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eB\/B:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eDog is homozygous for normal allele; no recessive alleles for chocolate\/liver brown are present, dog will transfer dominant alleles to the entire of its offspring.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eB\/b:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eDog is heterozygous for chocolate\/liver brown when one of recessive alleles is present (for example Bc\/bc, Bs\/Bs, Bd\/Bd), brown colour is not expressed, one recessive allele can be transferred to offspring.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eb\/b:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eDog is chocolate\/liver brown (homozygous for brown colour) in eumelanin pigmented areas and carries at least two recessive alleles (identical or different), which means that dog is either homozygous for one allele (for example b\u003csup\u003ec\u003c\/sup\u003e\/b\u003csup\u003ec\u003c\/sup\u003e, B\u003csup\u003es\u003c\/sup\u003e\/B\u003csup\u003es\u003c\/sup\u003e, B\u003csup\u003ed\u003c\/sup\u003e\/B\u003csup\u003ed\u003c\/sup\u003e) or heterozygous for two alleles (for example B\u003csup\u003ec\u003c\/sup\u003e\/b\u003csup\u003ec\u003c\/sup\u003e, B\u003csup\u003es\u003c\/sup\u003e\/b\u003csup\u003es\u003c\/sup\u003e, B\u003csup\u003ed\u003c\/sup\u003e\/B\u003csup\u003ed\u003c\/sup\u003e).\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003c\/tbody\u003e\u003c\/table\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eWhen two, three or four single copy variants of b\u003csup\u003ec\u003c\/sup\u003e, b\u003csup\u003ed\u003c\/sup\u003e, b\u003csup\u003es\u003c\/sup\u003e or b\u003csup\u003eaus\u003c\/sup\u003e are detected, the presence of multiple variants on a single copy of the gene cannot be excluded. Therefore, the overall B-Locus genotype for a dog could be B\/b or b\/b (the dog can appear black or brown) and cannot be determined by the laboratory without additional testing of parents.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113813856579,"sku":"2700014","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_5bb657d1-87cc-4efa-80d0-e2e4d2236e4c.jpg?v=1769440068"},{"product_id":"b-lokus-lancashire-heeler","title":"B-Locus (Lancashire Heeler)","description":"\u003cp\u003eGene TYRP1 (Tyrosinase related protein 1) is responsible for chocolate\/liver brown colour in dogs. This coat colour is inherited recessively. There are 4 different variants on B-Locus in Lancashire Heeler: b\u003csup\u003ec\u003c\/sup\u003e, b\u003csup\u003es\u003c\/sup\u003e, b\u003csup\u003ed\u003c\/sup\u003e and b\u003csup\u003ee\u003c\/sup\u003e. Combination of any two recessive alleles will result in chocolate\/liver brown colour (for example two b\u003csup\u003ec\u003c\/sup\u003e alleles or one b\u003csup\u003ec\u003c\/sup\u003e and one b\u003csup\u003es\u003c\/sup\u003e allele).\u003c\/p\u003e\u003cp\u003eBecause TYRP1 gene is related to eumelanin production, it only affects dogs which have genotype E\/E or E\/e on E-Locus. B-Locus also affects colour of the nose, eyes and pads. Dogs with genotype e\/e produce only pheomelanin in coat but production of eumelanin in the nose, eyes and pads is not affected and therefore totally controlled by B-Locus. Depending on genotypes of E and B-Loci dog can have yellow coat and brown nose\/eyes (e\/e, b\/b) or chocolate coat and brown nose\/eyes (E\/e or E\/E and b\/b).\u003c\/p\u003e\u003cp\u003eTest for B-Locus in Lancashire Heeler consists of four separate tests in order to find the presence of recessive alleles (b\u003csup\u003ec\u003c\/sup\u003e, b\u003csup\u003es\u003c\/sup\u003e, b\u003csup\u003ed\u003c\/sup\u003e and b\u003csup\u003ee\u003c\/sup\u003e). Results are presented as combined results as well as results for each single allele tested.\u003c\/p\u003e\u003ctable style=\"min-width: 50px;\"\u003e\u003ccolgroup\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003c\/colgroup\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eGenotype\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eB\/B:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eDog is homozygous for normal allele; no recessive alleles for chocolate\/liver brown are present, dog will transfer dominant alleles to the entire of its offspring.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eB\/b:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eDog is heterozygous for chocolate\/liver brown when one of recessive alleles is present (for example Bc\/bc, Bs\/Bs, Bd\/Bd), brown colour is not expressed, one recessive allele can be transferred to offspring.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eb\/b:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eDog is chocolate\/liver brown (homozygous for brown colour) in eumelanin pigmented areas and carries at least two recessive alleles (identical or different), which means that dog is either homozygous for one allele (for example b\u003csup\u003ec\u003c\/sup\u003e\/b\u003csup\u003ec\u003c\/sup\u003e, B\u003csup\u003es\u003c\/sup\u003e\/B\u003csup\u003es\u003c\/sup\u003e, B\u003csup\u003ed\u003c\/sup\u003e\/B\u003csup\u003ed\u003c\/sup\u003e) or heterozygous for two alleles (for example B\u003csup\u003ec\u003c\/sup\u003e\/b\u003csup\u003ec\u003c\/sup\u003e, B\u003csup\u003es\u003c\/sup\u003e\/b\u003csup\u003es\u003c\/sup\u003e, B\u003csup\u003ed\u003c\/sup\u003e\/B\u003csup\u003ed\u003c\/sup\u003e).\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003c\/tbody\u003e\u003c\/table\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eWhen two, three or four single copy variants of b\u003csup\u003ec\u003c\/sup\u003e, b\u003csup\u003ed\u003c\/sup\u003e, b\u003csup\u003es\u003c\/sup\u003e or b\u003csup\u003ee\u003c\/sup\u003e are detected, the presence of multiple variants on a single copy of the gene cannot be excluded. Therefore, the overall B-Locus genotype for a dog could be B\/b or b\/b (the dog can appear black or brown) and cannot be determined by the laboratory without additional testing of parents.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113813987651,"sku":"2700015","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_2a4b8847-1801-4ad7-9858-39081778c375.jpg?v=1769440076"},{"product_id":"b-lokus-siberian-husky","title":"B-Locus (Siberian Husky)","description":"\u003cp\u003eGene TYRP1 (Tyrosinase related protein 1) is responsible for chocolate\/liver brown colour in dogs. This coat colour is inherited recessively. There are 4 different variants on B-Locus in Siberian Husky: b\u003csup\u003ec\u003c\/sup\u003e, b\u003csup\u003es\u003c\/sup\u003e, b\u003csup\u003ed\u003c\/sup\u003e and b\u003csup\u003eh\u003c\/sup\u003e. Combination of any two recessive alleles will result in chocolate\/liver brown colour (for example two b\u003csup\u003ec\u003c\/sup\u003e alleles or one b\u003csup\u003ec\u003c\/sup\u003e and one b\u003csup\u003es\u003c\/sup\u003e allele).\u003c\/p\u003e\u003cp\u003eBecause TYRP1 gene is related to eumelanin production, it only affects dogs which have genotype E\/E or E\/e on E locus. B-Locus  also affects colour of the nose, eyes and pads. Dogs with genotype e\/e produce only pheomelanin in coat but production of eumelanin in the nose, eyes and pads is not affected and therefore totally controlled by B-Locus . Depending on genotypes of E and B-Loci dog can have yellow coat and brown nose\/eyes (e\/e, b\/b) or chocolate coat and brown nose\/eyes (E\/e or E\/E and b\/b).\u003c\/p\u003e\u003cp\u003eTest for B-Locus in Siberian Husky consists of four separate tests in order to find the presence of recessive alleles (b\u003csup\u003ec\u003c\/sup\u003e, b\u003csup\u003es\u003c\/sup\u003e, b\u003csup\u003ed\u003c\/sup\u003e and b\u003csup\u003eh\u003c\/sup\u003e). Results are presented as combined results as well as results for each single allele tested.\u003c\/p\u003e\u003ctable style=\"min-width: 50px;\"\u003e\u003ccolgroup\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003c\/colgroup\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eGenotype\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eB\/B:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eDog is homozygous for normal allele; no recessive alleles for chocolate\/liver brown are present, dog will transfer dominant alleles to the entire of its offspring.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eB\/b:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eDog is heterozygous for chocolate\/liver brown when one of recessive alleles is present (for example Bc\/bc, Bs\/Bs, Bd\/Bd), brown colour is not expressed, one recessive allele can be transferred to offspring.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eb\/b:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eDog is chocolate\/liver brown (homozygous for brown colour) in eumelanin pigmented areas and carries at least two recessive alleles (identical or different), which means that dog is either homozygous for one allele (for example b\u003csup\u003ec\u003c\/sup\u003e\/b\u003csup\u003ec\u003c\/sup\u003e, B\u003csup\u003es\u003c\/sup\u003e\/B\u003csup\u003es\u003c\/sup\u003e, B\u003csup\u003ed\u003c\/sup\u003e\/B\u003csup\u003ed\u003c\/sup\u003e) or heterozygous for two alleles (for example B\u003csup\u003ec\u003c\/sup\u003e\/b\u003csup\u003ec\u003c\/sup\u003e, B\u003csup\u003es\u003c\/sup\u003e\/b\u003csup\u003es\u003c\/sup\u003e, B\u003csup\u003ed\u003c\/sup\u003e\/B\u003csup\u003ed\u003c\/sup\u003e).\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003c\/tbody\u003e\u003c\/table\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eWhen two, three or four single copy variants of b\u003csup\u003ec\u003c\/sup\u003e, b\u003csup\u003ed\u003c\/sup\u003e, b\u003csup\u003es\u003c\/sup\u003e or b\u003csup\u003eh\u003c\/sup\u003e are detected, the presence of multiple variants on a single copy of the gene cannot be excluded. Therefore, the overall B-Locus genotype for a dog could be B\/b or b\/b (the dog can appear black or brown) and cannot be determined by the laboratory without additional testing of parents.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113814020419,"sku":"2700016","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_9d32ffb0-17b9-48ca-a373-0fde08b04fb2.jpg?v=1769440085"},{"product_id":"komplement-3-defizienz-epagneul-breton","title":"Complement 3 Deficiency (Brittany)","description":"\u003cp\u003eCanine C3 deficiency is a hereditary disorder affecting the Brittany Spaniel. The Complement Component C3 is an important protein of the immune system and is crucial for dog's ability to prevent bacterial infections. The mutation prohibits the formation of protein's functional units and the chain of one's defence mechanisms is broken. Signs of C3 deficiency often first appear in young dogs. Affected individuals show a predisposition to recurrent bacterial infections and to type 1 membranoproliferative glomerulonephritis. They suffer from skin infections, infections of the uterine tract and respiratory infections like pneumonia. As a result of this condition kidney disease can develop early in life where dogs show signs of decreased appetite and increased thirst and urination. This often leads to chronic kidney failure and shortened life span. Young dogs suffering from this disease are also very susceptible to developing hereditary muscle disease.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e C3 gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113814053187,"sku":"2700017","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_24e52b6d-b8ce-4511-b974-106397a5b4d8.jpg?v=1769440094"},{"product_id":"leukozyten-adhasionsdefizienz-typ-i-clad-irish-setter","title":"Leukocyte Adhesion Deficiency Type I (CLAD) - Irish Setter","description":"\u003cp\u003eCanine leukocyte adhesion deficiency (CLAD) is a lethal recessive autosomal immunodeficiency disease in Irish Setters. The condition of CLAD is characterized by recurrent infections, impaired wound healing and impaired leucocyte bactericidal activity. Puppies usually die very early from recurrent and multiple infections of the lungs and the skin. The signs are often confused with those of non-specific infections, making it difficult to diagnose the condition and to assess the extent of penetration of the mutant allele into the local population. The condition is characterized by a decreased production of b-2 integrin, a cell surface receptor that is critical for cell–cell and cell extracellular matrix interactions, due to the missense mutations in its gene (ITGB2).\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e ITGB2 gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113814315331,"sku":"2700018","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_429a2e3d-3860-4e50-a857-a8b45a151d9f.jpg?v=1769440103"},{"product_id":"multifokale-retinopathie-3-cmr3","title":"Multifocal Retinopathy 3 (CMR3)","description":"\u003cp\u003eCanine multifocal retinopathies (CMR) are a group of inherited eye diseases. The diseases were reported in mastiff-related breeds (CMR1), Coton de Tulear (CMR2) and in Lapponian herder (CMR3). CMR1 is found in different dog breeds, whereas CMR2 and CMR3 are so far exclusive to a single dog breed each. While exhibiting similar clinical symptoms comparable to CMR1 and CMR2, CMR3 is predicted to be based on a distinctly different molecular mechanism. CMR3 manifests in grey, tan or pink subretinal fluid in the eye, retinal elevations and generalized progressive retinal atrophy. The age of onset of the multifocal retinopathy ranges from 9 months to 2 years. Some of the individual lesions can disappear over time. The majority of CMR3 affected dogs have a typical CMR phenotype, while some can develop a more indistinguishable phenotype from multifocal retinal dysplasia or generalized retinal degeneration.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e BEST1 gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113814413635,"sku":"2700019","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_938c9b28-cbae-4db6-bc58-fb902404138b.jpg?v=1769440111"},{"product_id":"multifokale-retinopathie-1-cmr1","title":"Multifocal Retinopathy 1 (CMR1)","description":"\u003cp\u003eCanine multifocal retinopathy (CMR1) is an autosomal recessive genetic eye disorder similar to Best macular dystrophy in humans. Causative mutation in BEST1 gene generates a premature stop codon, which results in non-functional protein responsible for proper formation of pigment epithelium in retina. Typical clinical findings include multifocal areas of retinal elevation which progress to multifocal areas of outer retinal atrophy. In affected animals, the disease develops before 4 months of age and might progress slowly. Some affected animals do not show symptoms until later in life.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e BEST1 gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113814479171,"sku":"2700020","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_3b07567b-6210-4597-a7da-662dc1aaf07e.jpg?v=1769440120"},{"product_id":"multifokale-retinopathie-2-cmr2","title":"Multifocal Retinopathy 2 (CMR2)","description":"\u003cp\u003eCanine multifocal retinopathy (CMR2) is an autosomal recessive genetic eye disorder similar to Best macular dystrophy in humans. Causative mutation in BEST1 gene generates a premature stop codon, which results in non-functional protein responsible for proper formation of pigment epithelium in retina. Typical clinical findings include multifocal areas of retinal elevation which progress to multifocal areas of outer retinal atrophy. In affected animals, the disease develops before 4 months of age and might progress slowly. Some affected animals do not show symptoms until later in life.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e BEST1 gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113814610243,"sku":"2700021","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_aa557cbd-e2f2-46e3-b7dd-32867ad7c247.jpg?v=1769440128"},{"product_id":"kardiomyopathie-und-juvenile-mortalitat-cjm","title":"Cardiomyopathy and Juvenile Mortality (CJM)","description":"\u003cp class=\"text-align-justify\"\u003eCardiomyopathy and juvenile mortality (CJM) is a hereditary disease in Belgian Shepherd Dog breed. The clinical phenotype of this disease is unspecific and variable. Puppies are usually born without any visible signs of the disease. At the age of six to eight weeks after normal development puppies usually die. Only a few days prior the death they show some of various clinical signs such as vomiting, dyspnoea, lethargy and muscle twitching. In one of the research pathologists have found the cardiomyocytes of affected puppies were swollen and pale, and the sarcoplasm around the nucleus was dispersed by finely granular material. The cause of the disease and death are likely due to the degenerative changes in the heart, leading to myocardial failure.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e YARS2 gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113814643011,"sku":"2700023","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_75965701-a3bd-44c7-8fa4-b008008ab6cd.jpg?v=1769440136"},{"product_id":"cns-atrophie-mit-zerebellarer-ataxie-caca","title":"CNS Atrophy with Cerebellar Ataxia (CACA)","description":"\u003cp\u003eAtaxias are an inherited group of disorders of balance, coordination and tremors. They are often caused by a dysfunction of the cerebellum and thereby gaining the name cerebellar ataxia. A form of an inherited cerebellar ataxia in a family of a Belgian Shepherd dogs has been named central nervous system atrophy and cerebellar ataxia (CACA). Affected dogs show signs of uncoordinated movements, intention tremor, general elevated muscle tone and reduced swallowing reflex. First obvious signs are evident at 12-14 days of age and progress thereafter. Affected puppies gain less bodyweight in comparison to the unaffected ones. Severity of clinical signs vary, some puppies need to be euthanized due to the severity of the disorder, others stay in a relatively stable condition with noticeable ataxia. Genetic defect causes a complete absence of a protein that is required to transport selenium to the CNS. Total selenium concentration in the blood of affected homozygous puppies drops to 30% in comparison to a healthy wild type.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e SELENOP gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113814675779,"sku":"2700024","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_4af2282b-aaa9-41d0-80d4-a2c34ded99a7.jpg?v=1769440144"},{"product_id":"zerebellare-ataxie-ca1","title":"Cerebellar Ataxia (CA1)","description":"\u003cp\u003eCerebellar ataxia is a recessively inherited neurological disease, which exist in several genetically distinct forms. It causes a cytoplasmic accumulation of granular material within cerebellar cells, which leads to a cerebellar dysfunction that results in uncoordinated movements and intention tremor. Clinical signs appear at just few weeks after birth, stabilized at around six weeks of age, but remain visible into adulthood. Due to severe clinical phenotype and symptoms, affected dogs commonly have to be euthanized.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e RALGAPA1 gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113814708547,"sku":"2700026","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_7c184eae-90fd-4970-9b66-b9a192697204.jpg?v=1769440153"},{"product_id":"zerebellare-ataxia-finnish-hound","title":"Cerebellar Ataxia - Finnish Hound","description":"\u003cp\u003eCerebellar ataxia is a hereditary recessive autosomal disease that occurs in many species, including dogs, among which the Finnish Hound suffers from an early on-set disorder. It is characterized by degeneration of the cerebellar structures, which results in progressive motor incoordination. The symptoms usually occur at the age of 3 months and include progressing generalized cerebellar ataxia, difficulties in coordinating movements and balance, tremors and failure to thrive. Affected puppies have to be euthanised due to rapidly worsening symptoms.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e SEL1L gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113814741315,"sku":"2700027","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_d03195e8-443b-4c03-aa4b-be03deda2ebe.jpg?v=1769440161"},{"product_id":"inflammatorische-myopathie-cdmc-hollandischer-schaferhund","title":"Inflammatory Myopathy (CDMC) - Hollands Herder","description":"\u003cp\u003eInflammatory Myopathy (CDMC) is a disease that affects cerebellum (the area of brain that controls coordination and balance) and muscles. Also, the disease can involve other parts of the central nervous system, such as, the spinal cord, medulla oblongata, cerebral cortex and brain stem. Cerebellar degeneration is the result of inherited genetic mutations that affect the normal production of specific proteins necessary for the survival of neurons. Clinical symptoms of affected dogs are characteristic wide-based walk, neuromuscular weakness, tremor in the trunk of the body, loss of balance, tripping as well as falling. Other clinical signs may include episodes of marked movements during sleep, noise phobia, gait abnormalities and anxiety. The first symptoms start at 3 to 9 months of age. Affected dogs are usually euthanized prior to 2 years of age due to painful muscular degeneration.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e SLC25A12 gene\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113814806851,"sku":"2700028","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_df799dcf-7711-41b1-b594-936115557ed6.jpg?v=1769440170"},{"product_id":"cerebellare-degeneration-mit-myositis-cdmc-nova-scotia-duck-tolling-retriever","title":"Cerebellar degeneration and myositis complex (CDMC) - Nova Scotia Duck Tolling Retriever","description":"\u003cp\u003eCerebellar degeneration and myositis complex (CDMC) is a disease that affects cerebellum (the area of brain that controls coordination and balance) and muscles. Also, the disease can involve other parts of the central nervous system, such as, the spinal cord, medulla oblongata, cerebral cortex and brain stem. Cerebellar degeneration is the result of inherited genetic mutations that affect the normal production of specific proteins necessary for the survival of neurons. Clinical symptoms of affected dogs are characteristic wide-based walk, neuromuscular weakness, tremor in the trunk of the body, loss of balance, tripping as well as falling. Other clinical signs may include episodes of marked movements during sleep, noise phobia, gait abnormalities and anxiety. The first symptoms start at 3 to 9 months of age. Affected dogs are usually euthanized prior to 2 years of age due to painful muscular degeneration.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e SLC25A12 gene\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113814872387,"sku":"2700029","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_48a05e0d-b0d9-4627-889d-6b492478be1e.jpg?v=1769440179"},{"product_id":"cerebellare-hypoplasie-ch","title":"Cerebellar Hypoplasia (CH)","description":"\u003cp\u003eCerebellar hypoplasia is an autosomal recessive neurological disorder. It is described by anatomical abnormalities in the brain - smaller or undeveloped cerebellum. The puppies are born clinically normal. First symptoms occur at around 2 weeks of age and include failure of gaining weight, progressive ataxia, trouble to stand and walk in a straight line, no spontaneous or positional nystagmus and congenital brain defect. Affected individuals usually have to be euthanised at around 4 weeks of age due to severe progressive symptoms.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e \u003cspan lang=\"EN-US\"\u003eRELN\u003c\/span\u003e gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113815331139,"sku":"2700030","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_60a6e35f-f2a3-4a52-aa11-a434fe1fac35.jpg?v=1769440188"},{"product_id":"charcot-marie-tooth-neuropathie-cmt","title":"Charcot-Marie-Tooth Neuropathy (CMT)","description":"\u003cp\u003eCharcot-Marie-Tooth Neuropathy (CMT) disease is the most common neuromuscular disorder in humans. In dogs, CMT-like diseases occur naturally as it was described in many different breeds. In the breed Miniature Schnauzer, a variant in the SBF2 gene has been found to cause Charcot-Marie-Tooth neuropathy (CMT). A mutation in this gene is responsible for the occurrence of a demyelinating peripheral neuropathy with abnormally folded myelin. Affected dogs present clinical signs of laryngeal paralysis or megaoesophagus. Most of them show regurgitations caused by megaoesophagus and inspiratory dyspnoea caused by laryngeal paralysis. Age of onset and clinical presentation is less than 2 years. In the previously described cases, affected dogs have been alive more than 3 years following diagnosis which indicates a long survival rate.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e SBF2 gene\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113815363907,"sku":"2700031","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_15975de2-9602-46d1-99a2-844c6aeb07ea.jpg?v=1769440197"},{"product_id":"chondrodysplasie-chondrodystrophie-und-veranlagung-zu-bandscheibenvorfallen-cdpa-cddy-ivdd","title":"Chondrodysplasia, Intervertebral Disc Disease Risk Factor and Chondrodystrophy (CDPA\/CDDY – IVDD)","description":"\u003cp\u003eOne of the most prominent characteristics defining many dog breeds are extremely short limbs. This morphological feature is the result of abnormal growth of developing limbs due to defects in the process of endochondral ossification. Short limbs were associated with two conditions: chondrodysplasia and chondrodystrophy. Chondrodysplasia (CDPA) is defined as an inherited condition characterized by abnormal growth at the ends of bones, particularly the long bones. In dogs CDPA was associated with FGF4 gene insertion on chromosome 18, which is inherited as autosomal dominant trait and found to cause short legged phenotype in Basset Hound, Welsh Corgi, Dachshund, West Highland White Terrier and Scottish Terrier. Chondrodystrophy (CDDY) in dogs is defined by dysplastic, shortened long bones and premature degeneration and calcification of intervertebral discs- type I intervertebral disc disease (IVDD). Abnormal discs are predisposed to herniation leading to IVDD in dogs at young age. CDDY\/IVDD was associated with FGF4 gene insertion on chromosome 12, which is inherited in semi-dominant manner in respect to height (dogs with 2 copies of the mutation have shorter legs than dogs with one copy of the mutation) and dominant for IVDD (dogs with one or two copies of the mutation are at risk for IVDD). This mutation was found in many dog breeds.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal dominant\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e FGF4 gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113815396675,"sku":"2700032","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_47203afe-168d-4a78-b598-84bc419b273b.jpg?v=1769440205"},{"product_id":"cirneco-oculo-neurologisches-syndrom-cons","title":"Cirneco Oculo-Neurological Syndrome (CONS)","description":"\u003cp\u003eCirneco oculo-neurological syndrome (CONS) is an autosomal recessive disorder characterized by retinal and neurological manifestations. The clinical signs of affected dogs include degeneration of retinal photoreceptors causing a loss of sight, along with paroxysmal neurological episodes consisting of head tremors and involuntary movements of one of the front limbs. The episodes are sporadic and described as either atypical seizures or paroxysmal dyskinesias. The retinal abnormalities are typically detected around 4 years of age, meanwhile the neurological abnormalities are likely to be present much earlier, at around 2–2.5 years of age.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e AMPD2 gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113815626051,"sku":"2700034","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_6da96e12-b85a-466a-b897-2cfbfe136c1b.jpg?v=1769440214"},{"product_id":"gaumenspalte-und-syndaktylie-clps","title":"Cleft lip\/Palate and Syndactyly (CLPS)","description":"\u003cp\u003eCleft palate is a genetically inherited craniofacial birth defect affecting Nova Scotia Duck Tolling Retrievers, amongst other breeds. The defect is caused by a disruption in the secondary palate development, which is the bony structure separating the nose from the mouth, resulting in a hole or cleft in the palate. The cleft palate is accompanied by an uneven alignment of the upper and lower jaw, shorter mandibles, poorly developed or absent nasal septum and posteriorly placed tongue. The affected dogs show difficulties in feeding, with a high risk of aspiration pneumonia due to food entering the cleft. The disorder manifests itself during early stages of embryonic development.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e DLX6 gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113815658819,"sku":"2700035","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_f472a4a0-3cc4-4663-924e-848cf339bc58.jpg?v=1769440223"},{"product_id":"c-lokus-albino-okulokutaner-albinismus","title":"C-Locus (Albino, Oculocutaneous Albinism)","description":"\u003cp\u003eAlbinism is a rare genetic disorder characterized by inability to produce pigmentation. There are 2 types of albinism. Oculocutaneous albinism (OCA) affects pigmentation in skin, eyes and hair, while ocular albinism affects the eyes. OCA manifests in a complete lack of pigmentation resulting in a white cream color skin with pink nose, lips and paw pads. Not all dogs with “white” coats have albinism. Non-albino white dogs can be distinguished from albino dogs because their nose, skin and lips have normal pigmentation. Affected dogs show signs of photophobia in full sunlight which is resolved indoor in normal light. Albinism has been recorded in different breeds and is caused by different breed-specific mutations.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113818247491,"sku":"2700036","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_063d8dd0-86fa-4f9b-9572-9792262e4548.jpg?v=1769440232"},{"product_id":"farbverdunnung-und-neurologische-defekte-cdn","title":"Coat Colour Dilution and Neurological Defects (CDN)","description":"\u003cp\u003eCoat colour dilution and neurological defects (CDN) are a group of rare genetic diseases resembling human Griscelli Syndrome Type 1. The disease has been investigated miniature dachshund. Affected dogs show a dilute red colour, which is much lighter than the standard red colour of non-affected dogs. Affected puppies can’t keep their bodies in a normal position, can’t maintain an upright head position and keep falling on their side.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e MYO5A gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113818313027,"sku":"2700037","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_9a3d4f10-8657-4a48-917f-0c18b0c16e18.jpg?v=1769440240"},{"product_id":"l1-lokus-langhaar-haufige-variant","title":"L1-Locus Long Hair (Common Variant)","description":"\u003cp\u003eHair length is one of the most important morphological body traits of dogs. Differences in coat length are visible in various dog breeds, but for some, the breed standard allows only one coat length (long or short variant is unacceptable). One such example is Pembroke Welsh Corgis where longhaired dogs (also called 'fluffies') are not allowed according to the breed standard.\u003c\/p\u003e\u003cp\u003eIn our laboratory, we test 3 out of 5 known mutations on the FGF5 gene responsible for hair length:\u003c\/p\u003e\u003cul\u003e\u003cli\u003e\u003cp\u003e\u003cstrong\u003eL1: c.284G\u0026gt; T\u003c\/strong\u003e mutation is responsible for hair length in \u003cem\u003emany dog breeds\u003c\/em\u003e,\u003c\/p\u003e\u003c\/li\u003e\u003cli\u003e\u003cp\u003e\u003cstrong\u003eL2: c.578C\u0026gt; T\u003c\/strong\u003e mutation occurs in \u003cem\u003eAkita, Siberian Husky, and Samoyed breeds\u003c\/em\u003e\u003c\/p\u003e\u003c\/li\u003e\u003cli\u003e\u003cp\u003e\u003cstrong\u003eL4: c.559_560dupGG\u003c\/strong\u003e mutation occurs in \u003cem\u003eFrench Bulldog, Afghan hounds and Eurasier\u003c\/em\u003e.\u003c\/p\u003e\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eIn some breeds more than one mutation can occur. For example, in French Bulldog L1 and L4 mutations can cause long coat.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e autosomal recessive\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e FGF5 gene\u003c\/p\u003e\u003ctable style=\"min-width: 50px;\"\u003e\u003ccolgroup\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003c\/colgroup\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eGenotype\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eN\/N:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog has short hair.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eN\/L:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog has short hair, but carries one copy of the variant gene which may be transmitted to offspring.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eL\/L:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog has long hair\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003c\/tbody\u003e\u003c\/table\u003e\u003cp\u003e\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113818444099,"sku":"2700038","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_13e430c8-a021-4d9c-87a9-cd8208738a48.jpg?v=1769440249"},{"product_id":"l2-lokus-langhaar-akita","title":"L2-Locus Long Hair (Akita)","description":"\u003cp\u003eHair length is one of the most important morphological features of dogs. Differences in coat length are visible in various dog breeds, but for some, the breed standard allows only one coat length (long or short variant is unacceptable). One such example is Pembroke Welsh Corgis where longhaired dogs (also called 'fluffies') are not allowed according to the breed standard.\u003c\/p\u003e\u003cp\u003eIn our laboratory, we test 3 out of 5 known mutations on the FGF5 gene responsible for hair length:\u003c\/p\u003e\u003cul\u003e\u003cli\u003e\u003cp\u003e\u003cstrong\u003eL1: c.284G\u0026gt; T\u003c\/strong\u003e mutation is responsible for hair length in \u003cem\u003emany dog breeds\u003c\/em\u003e,\u003c\/p\u003e\u003c\/li\u003e\u003cli\u003e\u003cp\u003e\u003cstrong\u003eL2: c.578C\u0026gt; T\u003c\/strong\u003e mutation occurs in \u003cem\u003eAkita, Siberian Husky, and Samoyed breeds\u003c\/em\u003e\u003c\/p\u003e\u003c\/li\u003e\u003cli\u003e\u003cp\u003e\u003cstrong\u003eL4: c.559_560dupGG\u003c\/strong\u003e mutation occurs in \u003cem\u003eFrench Bulldog, Afghan hounds and Eurasier\u003c\/em\u003e.\u003c\/p\u003e\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eIn some breeds more than one mutation can occur. For example, in French Bulldog L1 and L4 mutations can cause long coat.\u003c\/p\u003e\u003ctable style=\"min-width: 50px;\"\u003e\u003ccolgroup\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003c\/colgroup\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eGenotype\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eN\/N:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog has short hair.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eN\/L:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog has short hair, but carries one copy of the variant gene which may be transmitted to offspring.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eL\/L:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog has long hair\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003c\/tbody\u003e\u003c\/table\u003e\u003cp\u003e\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113818476867,"sku":"2700039","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_a9a55176-fada-4dc9-97fd-f2fac42bfa46.jpg?v=1769440258"},{"product_id":"l4-lokus-langhaar-afghane-franzosische-bulldogge","title":"L4-Locus Long Hair (Afghan Hound, French Bulldog))","description":"\u003cp\u003eHair length is one of the most important morphological features of dogs. Differences in coat length are visible in various dog breeds, but for some, the breed standard allows only one coat length (long or short variant is unacceptable). One such example is Pembroke Welsh Corgis where longhaired dogs (also called 'fluffies') are not allowed according to the breed standard.\u003c\/p\u003e\u003cp\u003eIn our laboratory, we test 3 out of 5 known mutations on the FGF5 gene responsible for hair length:\u003c\/p\u003e\u003cul\u003e\u003cli\u003e\u003cp\u003e\u003cstrong\u003eL1: c.284G\u0026gt; T\u003c\/strong\u003e\u0026nbsp;mutation is responsible for hair length in\u0026nbsp;\u003cem\u003emany dog breeds\u003c\/em\u003e, \u0026nbsp;\u003c\/p\u003e\u003c\/li\u003e\u003cli\u003e\u003cp\u003e\u003cstrong\u003eL2: c.578C\u0026gt; T\u003c\/strong\u003e\u0026nbsp;mutation occurs in\u0026nbsp;\u003cem\u003eAkita, Siberian Husky, and Samoyed breeds\u003c\/em\u003e\u003c\/p\u003e\u003c\/li\u003e\u003cli\u003e\u003cp\u003e\u003cstrong\u003eL4: c.559_560dupGG\u003c\/strong\u003e\u0026nbsp;mutation occurs in\u0026nbsp;\u003cem\u003eFrench Bulldog, Afghan hounds and Eurasier\u003c\/em\u003e.\u003c\/p\u003e\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eIn some breeds more than one mutation can occur. For example, in French Bulldog L1 and L4 mutations can cause long coat.\u003c\/p\u003e\u003ctable style=\"min-width: 50px;\"\u003e\u003ccolgroup\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003c\/colgroup\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eGenotype\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eN\/N:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog has short hair.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eN\/L:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog has short hair, but carries one copy of the variant gene which may be transmitted to offspring.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003e\u003cstrong\u003eL\/L:\u003c\/strong\u003e\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog has long hair\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003c\/tbody\u003e\u003c\/table\u003e\u003cp\u003e\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113818575171,"sku":"2700040","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_5050bdf9-8512-4369-b0de-efdce238f60c.jpg?v=1769440267"},{"product_id":"co-lokus-cocoa-braun-franzosische-bulldogge","title":"Co-Locus Cocoa Brown (French Bulldog)","description":"\u003cp\u003eBrown or chocolate coat color is frequent in many dog breeds due to variants at the B-Locus on TYRP1 gene. In French bulldog two variants in two different genes (TYRP1 and HPS3) were associated with brown coat color. There are subtle but clear differences in coat, skin and eye color between TYRP1 and HPS3 homozygous dogs. Dogs with two copies of HPS3 mutation have a slightly darker coat color and lighter eyes than the TYRP1 related brown dogs. The HPS3 gene related brown coat color in French bulldog was named cocoa. Cocoa in adult dogs appears slightly darker as in young dogs.\u003c\/p\u003e\u003cp\u003eDifferent research shows that most of brown French bulldogs are due to variants on HPS3 gene or\/and TYRP1 gene. Findings of one research group and testing data in our laboratory suggest that a small number of brown French bulldogs do not possess any of the causal variants. We therefore anticipate that there are some other, yet uncharacterized causal variants, which can cause brown colour in French bulldogs.\u003c\/p\u003e\u003ctable style=\"min-width: 50px;\"\u003e\u003ccolgroup\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003ccol style=\"min-width: 25px;\"\u003e\u003c\/colgroup\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eN\/N\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eVariant for cocoa is not present. The dog will always pass on the 'N' allele to any potential offspring.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eCO\/N\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog carries one copy of 'cocoa' alelle and one copy of 'N' alelle. There is a 50% probability to transfer the 'cocoa' allele to the offspring.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003ctr\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eCO\/CO\u003c\/p\u003e\u003c\/td\u003e\u003ctd colspan=\"1\" rowspan=\"1\"\u003e\u003cp\u003eThe dog carries two copy of 'cocoa' alelle and it will express cocoa coat colour. The dog will transfer one recessive 'cocoa' allele to its entire offspring.\u003c\/p\u003e\u003c\/td\u003e\u003c\/tr\u003e\u003c\/tbody\u003e\u003c\/table\u003e\u003cp\u003e\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113818607939,"sku":"2700041","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_2628cb5b-158b-425c-95ec-f280b0d99f1a.jpg?v=1769440275"},{"product_id":"collie-eye-anomalie-cea","title":"Collie Eye Anomaly (CEA)","description":"\u003cp\u003eCollie eye anomaly (CEA, Choroidal Hypoplasia-CH) is a hereditary eye disease in dogs, characterized by different level of impairment of the retina and choroid sclera that occurs during development of the eye. The inheritable disease is not progressive and the state after eye development remains stable. For this disease no drugs exist and it cannot be treated. The main symptom in affected dogs is hypoplasia (under development) of choroid, which is an important layer of the eye under the retina. In dogs with more extensive CEA disease the hypoplasia of retina or coloboma development may occur. The extent of this disease is different in each dog. Known symptoms range from mild to very severe that can lead to blindness.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e NHEJ1 gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113818673475,"sku":"2700042","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_55b3ae3d-4b77-4f82-90bf-ff3adc3168ee.jpg?v=1769440283"},{"product_id":"spondylokostale-dysostose-comma-defect-scd","title":"Spondylocostal Dysostosis (Comma defect, SCD)","description":"\u003cp\u003eSpondylocostal dysostosis (SCD, Comma Defect) is a severe congenital disorder of the axial skeleton. The condition is characterised by a reduction in body length, truncal shortening, changes in vertebrae shape and rib anomalies. The hindquarters of affected pups is usually reduced in size compared to the forequarters, giving an overall comma-like morphology to the body. The malformation of the thorax and of the spine affects the respiratory function of lungs and the function of the spine. The rib cage is usually poorly developed with a reduced number of ribs, fusion of ribs and displaying malalignment. Affected pups are usually stillborn or die within hours of birth.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e HES7 gene\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113818706243,"sku":"2700043","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_93831619-77bc-4fbf-9c0a-38a8fb823a6d.jpg?v=1769440291"},{"product_id":"cone-degeneration-cd-deutsch-kurzhaar","title":"Cone Degeneration (CD) - German Shorthaired Pointer","description":"\u003cp\u003eCone degeneration (CD) is an autosomal recessive disease in dogs similar to human achromatopsia. The disease is characterized by day-blindness and absence of retinal cone function in adult dogs. The symptoms are only present in bright light, which means vision in dim light is normal. Affected dogs remain ophthalmoscopically normal through life because rod photoreceptors remain functionally and structurally unharmed. They develop day-blindness and photophobia around 8 to 12 weeks of age, when retinal development is normally completed in dogs.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e CNGB3 gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113820311875,"sku":"2700044","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_451ba09e-0a9d-4ca6-872a-f9b3673e0a60.jpg?v=1769440300"},{"product_id":"progressive-retinaatrophie-cone-rod-dystrophie-4-cord1-pra-cord1-crd4","title":"Progressive Retinal Atrophy, Cone-Rod Dystrophy 4\/cord1 (PRA-cord1\/crd4)","description":"\u003cp\u003eMost of canine retinal diseases with known causal mutations are rod-cone degenerations also known as progressive retinal atrophies (PRAs), which are characterized by progressive rod-led photoreceptor degenerations that is followed by cone photoreceptor demise. In contrast, cone-rod dystrophies are characterized by the relatively early loss of cone photoreceptors. Cone–rod dystrophy 1 (cord1 - PRA) is a retinal disease associated with RPGRIP1 gene first described in Dachshund. The earliest signs are detectable at approximately 6 months of age. By the 40th week of age, no photoreceptor function could be detected with ERG. One study reported that not all dogs homozygous for the mutation develop the disease, therefore it is speculated that other genetic factors may influence the disease. In all clinically affected dogs, mutation was found.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e RPGRIP1 gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113820377411,"sku":"2700045","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_07b5f89f-4479-4746-bb93-c6b81b7f0708.jpg?v=1769440308"},{"product_id":"progressive-retinaatrophie-cone-rod-dystrophie-1-american-pit-bull-terrier-pra-crd1","title":"Progressive Retinal Atrophy, Cone-Rod Dystrophy 1 (American Pit Bull Terrier) (PRA-crd1)","description":"\u003cp\u003eMost of canine retinal diseases with known causal mutations are rod-cone degenerations also known as progressive retinal atrophies (PRAs), which are characterized by progressive rod-led photoreceptor degeneration that is followed by cone photoreceptor demise. In contrast, cone-rod dystrophies are characterized by the relatively early loss of cone photoreceptors. Crd1 usually affects very young dogs (less than 1-year old) and causes severe photopic and scotopic visual impairment, which can progress to complete blindness in early adulthood. Mutation causing \u003cem\u003ecrd1\u003c\/em\u003e has been observed in American Staffordshire Terrier dogs. Because American Staffordshire Terrier dogs and American Pit Bull Terrier dogs are closely related breeds and are sometimes crossbred it is possible that the same mutation also appears at American Pit Bull Terrier dogs.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e PDE6B gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113820410179,"sku":"2700046","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_6fb973c1-7887-40e8-93fe-0bc964fbd1df.jpg?v=1769440316"},{"product_id":"progressive-retinaatrophie-cone-rod-dystrophie-pra-cord2-crd","title":"Progressive Retinal Atrophy, Cone-Rod Dystrophy (PRA-cord2\/crd)","description":"\u003cp\u003eMost of canine retinal diseases with known causal mutations are rod-cone degenerations also known as progressive retinal atrophies (PRAs), which are characterized by progressive rod-led photoreceptor degeneration that is followed by cone photoreceptor demise. In contrast, cone-rod dystrophies are characterized by the relatively early loss of cone photoreceptors and relative preservation of rod function. Cone-rod dystrophy 2 (cord2 - PRA) is a retinal disease associated with NPHP4 gene in Wirehaired Dachshund. First clinical signs can be detected already at the age of 5 weeks (reduced cone ERG response). Initial ophtalmoscopic changes are usually diagnosed between the age of 10 months to 3 years.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e NPHP4 gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113820442947,"sku":"2700047","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_b79e5ad2-f28b-4b6a-ae5b-a14d3563e01f.jpg?v=1769440325"},{"product_id":"progressive-retinaatrophie-cone-rod-dystrophie-2-pra-crd2","title":"Progressive Retinal Atrophy, Cone-Rod Dystrophy 2 (PRA-crd2)","description":"\u003cp\u003eMost of canine retinal diseases with known causal mutations are rod-cone degenerations, also known as progressive retinal atrophies (PRAs), characterized by progressive rod-led photoreceptor degenerations that is followed by cone photoreceptor demise. In contrast, cone-rod dystrophies are characterized by the relatively early loss of cone photoreceptors. Crd2-PRA usually affects very young dogs (less than 1-year old) and cause severe photopic and scotopic visual impairment, which can progress to complete blindness in early adulthood. Mutation causing \u003cem\u003ecrd2-PRA\u003c\/em\u003e has been observed in American Pit Bull Terrier dogs. Because American Pit Bull Terrier and American Staffordshire Terrier are closely related breeds and are sometimes crossbreed it is possible that the same mutation also appears in American Staffordshire Terrier.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e IQCB1 gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113822900547,"sku":"2700048","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_6dd547e5-b4b7-4c87-9bf8-9462711b3359.jpg?v=1769440333"},{"product_id":"kongenitale-dyshormonogene-hypothyreose-mit-kropf-cdhg","title":"Congenital Dyshormonogenic Hypothyroidism with Goiter (CDHG)","description":"\u003cp\u003eCongenital dyshormonogenic hypothyroidism with goiter (CDHG) is an autosomal recessive disorder, caused by lymphocytic destruction or idiopathic atrophy of the thyroid gland. The clinical signs include growth delay, low-intensity heart murmur, cough, exercise intolerance, goiter and dyshormonogenesis.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e SLC5A5 gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113823064387,"sku":"2700049","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_764c4dcc-ed6e-4d26-8048-69e21a6027bb.jpg?v=1769440341"},{"product_id":"angeborene-augenfehlbildung-cem","title":"Congenital Eye Malformation (CEM)","description":"\u003cp\u003eEye Malformations can be caused by environmental or genetic factors. A new form of CEM has been observed in Golden Retrievers with clinical signs including unilateral or bilateral retina dysplasia and\/or optic nerve hypoplasia. In some severe cases, dogs are euthanized due to bilateral changes, aggressivity, or some other severe clinical signs. A mutation in SIX6 gene has been observed in Golden Retrievers with CEM, suggesting a strong connection between the gene and the disease since this gene produces a transcription factor with a known role in eye development.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e Autosomal dominant with incomplete penetrance\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e SIX6 gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers, and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113823162691,"sku":"2700050","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_3a031363-7fe1-400a-bad4-415a0d7daebc.jpg?v=1769440350"},{"product_id":"kongenitale-hypothyreose-chg-toy-fox-terrier","title":"Congenital Hypothyroidism (CHG) - Toy Fox Terrier","description":"\u003cp class=\"text-align-justify\"\u003eCongenital hypothyroidism with goiter (CHG) in Toy Fox Terriers and Rat Terriers is an endocrine disorder characterized by inadequate T4 levels early in life concurrent with signs of hypothyroidism.  Without early diagnosis and treatment (oral thyroid hormone replacement therapy), typical clinical signs include growth retardation (dwarfism), delayed onset of developmental milestones such as eye opening and tooth eruption, abnormal hair and skin texture, epiphyseal dysplasia, mental retardation, unresponsiveness and lethargy. The disorder is lethal unless diagnosed and treated early. Congenital hypothyroidism in this breed is often presented with goiter - a swelling in the neck resulting from an enlarged thyroid gland.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e TPO gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113823195459,"sku":"2700051","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_fcd5c376-e2b2-4727-949c-78d8b0f9e979.jpg?v=1769440359"},{"product_id":"kongenitale-hypothyreose-chg-franzosische-bulldogge","title":"Congenital Hypothyroidism (CHG) - French Bulldog","description":"\u003cp\u003eCongenital hypothyroidism with goiter (CHG) is an inherited autosomal recessive disorder affecting the thyroid gland. Generally, CHG is an adult-onset disorder, but sometimes it also occurs in the neonatal period. It affects different dog breeds including Spanish water dog, Fox terrier, Tenterfield terrier, and French bulldog. Improper activity of specific proteins leads to inadequate levels of thyroid hormones, which manifests in symptoms like developmental delay, hypothyroidism, enlarged thyroid glands, and signs collectively known as cretinism. Puppies show signs of inactivity, delayed opening of eyes and ear canals. French bulldogs exhibit some unusual phenotypic features with near-normal epiphyseal ossification and closure which is in contrast with other breeds of dogs that do exhibit delayed closure of long bone and epiphyseal ossification.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e TPO gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers, and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113823260995,"sku":"2700052","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_0770b44e-6e45-49ed-a2ea-ad4207af7b39.jpg?v=1769440368"},{"product_id":"kongenitale-hypothyreose-chg-spanischer-wasserhund","title":"Congenital Hypothyroidism (CHG) - Spanish Water Dog","description":"\u003cp\u003eCongenital hypothyroidism with goiter (CHG) in Spanish Waterdog is an endocrine disorder characterized by inadequate T4 levels early in life concurrent with signs of hypothyroidism. Without early diagnosis and treatment (oral thyroid hormone replacement therapy), typical clinical signs include growth retardation (dwarfism), delayed onset of developmental milestones such as eye opening and tooth eruption, abnormal hair and skin texture, epiphyseal dysplasia, mental retardation, unresponsiveness and lethargy. The disorder is lethal unless diagnosed and treated early. Congenital hypothyroidism in this breed is often presented with goiter - a swelling in the neck resulting from an enlarged thyroid gland.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e TPO gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113823850819,"sku":"2700053","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_fbc61103-1e8b-4b91-94c2-129679721b8d.jpg?v=1769440377"},{"product_id":"kongenitale-hypothyreose-chg-tenterfield-terrier","title":"Congenital Hypothyroidism (CHG) - Tenterfield Terrier","description":"\u003cp\u003eCongenital hypothyroidism with goiter (CHG) is an endocrine disorder characterized by enlarged thyroid glands (goiter). The underlying cause of this disorder is an inability of the thyroid glands to produce sufficient hormone levels to inhibit the release of thyrotropin in the pituitary gland. This in turn causes structural abnormalities in the thyroid glands. The disorder can be inherited or acquired by dietary iodine deficiency or excess, or by exposure to goitrogenic compounds. Genetically inherited CHG occurs in several dog breeds, including Tenterfield Terriers. The affected dogs show growth failure with short legs at around 3 weeks of age. Other symptoms include later opening of eyes, severe mental retardation, opaque corneas, lethargy, abnormal coat texture, difficulty in nursing and enlarged thyroid glands causing neck swelling and obstructing the airways. CHG is a lethal disorder, but treatment is possible by early implementation of thyroid hormone replacement therapy. Genetic testing could be used to diagnose CGH early or to prevent future cases by carrier detection.\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eInheritance:\u003c\/strong\u003e \u003cem\u003eautosomal recessive\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMutation:\u003c\/strong\u003e  TPO gene\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGenetic test:\u003c\/strong\u003e The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.\u003c\/p\u003e","brand":"EXT","offers":[{"title":"Default Title","offer_id":54113824833859,"sku":"2700054","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/FERAGEN_Einzelanalysen_0d46d1a5-71e6-48e3-9347-c4a7e751d91e.jpg?v=1769440386"}],"url":"https:\/\/shop.feragen.at\/en\/collections\/xt.oembed?page=13","provider":"FERAGEN Shop","version":"1.0","type":"link"}