{"title":"Single Analysis","description":"","products":[{"product_id":"multidrug-resistance-1-medikamentenunvertraglichkeit","title":"MDR1 - Multidrug Resistance 1","description":"\u003cp style=\"font-weight: 400;\" data-mce-fragment=\"1\" data-mce-style=\"font-weight: 400;\"\u003eMultidrug resistance 1 or drug intolerance, MDR1 for short, is a congenital disease that occurs in many herding dog breeds. The mutation in the ABCB1 gene causes a malfunction of the P-glycoprotein, which is responsible for the breakdown of certain drugs and toxins in the body. Clinical symptoms are often associated with the distribution of drugs in the central nervous system. Based on reports that even carriers can develop symptoms of intolerance, it can be assumed that the inheritance is autosomal incompletely dominant rather than autosomal recessive. Autosomal incomplete dominant means that dogs that carry only one copy of the mutation are at increased risk of an adverse reaction to certain medications. Although side effects from certain medications are most often observed in dogs with two defective copies of the gene, the dosage of medications should be adjusted even in carriers of the MDR1 defect. If a dog at risk is treated with one or more common medications (see below*), there is a risk of developing neurological symptoms. These range from tremors and increased saliva production to vomiting, blindness, coma and even death. Because certain medications cannot be metabolized, even small doses can be fatal. Dogs affected by MDR1 show no symptoms unless they are exposed to certain medications. It is therefore important to inform the treating veterinarian about a known diagnosis in order to adapt therapy accordingly.\u003c\/p\u003e\n\n \u003cp style=\"font-weight: 400;\" data-mce-fragment=\"1\" data-mce-style=\"font-weight: 400;\"\u003e*Drugs known to cause neurological symptoms in MDR1 carriers or affected dogs:\u003c\/p\u003e\n\n\u003cp style=\"font-weight: 400;\" data-mce-fragment=\"1\" data-mce-style=\"font-weight: 400;\"\u003e Acepromazine, butorphanol, doxorubicin, emodepside, erythromycin, ivermectin, loperamide, milbemycin, moxidectin, rifampicin, selamectin, vinblastine and vincristine.\u003c\/p\u003e\n\n \u003cp style=\"font-weight: 400;\" data-mce-fragment=\"1\" data-mce-style=\"font-weight: 400;\"\u003eIn addition to the drugs mentioned here, there are many others that are removed from the central nervous system in humans via the P-glycoprotein mechanism. However, reports of drug-induced neurological dysfunctions caused by medications other than those listed here are rare in dogs. Please be sure to consult your veterinarian before administering medication to a dog that is an MDR1 carrier or affected by this disease. Even untested dogs from susceptible breeds should be treated with caution. In addition to the drugs mentioned here, there are many others that are removed from the central nervous system in humans via the P-glycoprotein mechanism. However, reports of drug-induced neurological dysfunctions caused by medications other than those listed here are rare in dogs. Please be sure to consult your veterinarian before administering medication to a dog that is an MDR1 carrier or affected by this disease. Even untested dogs from susceptible breeds should be treated with caution.\u003c\/p\u003e\n\n \u003cp style=\"font-weight: 400;\" data-mce-fragment=\"1\" data-mce-style=\"font-weight: 400;\"\u003eDelivery takes place as a standard letter. (Delivery time approx. 2-5 working days).\u003cbr data-mce-fragment=\"1\"\u003e Processing time after sample receipt in the laboratory: usually 7-10 working days.\u003cbr data-mce-fragment=\"1\"\u003e Examination material: oral mucosa swabs or 1-2 ml EDTA blood.\u003c\/p\u003e","brand":"FERAGEN","offers":[{"title":"Default Title","offer_id":47845559861571,"sku":"060046","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/MDR1_HeroImage.png?v=1707914125"},{"product_id":"episodische-aggression-belgischer-malinois-typ","title":"Episodic aggression (Belgian Malinois type)","description":"Episodic aggression is a neurological behavioural change that is found in Belgian Shepherds. The cause of this behavioural anomaly is an altered signal transmission of the neurotransmitter dopamine in the synapses. Affected dogs experience unpredictable seizures with increased aggression, which can occur episodically. Before an episodic seizure, the dogs often freeze (glazed look) and are neither responsive nor aware of their surroundings. The dog's condition is uncontrolled and can lead to aggressive behaviour, regardless of the actual character of the affected dog. Dogs with one gene copy of the A22 allele for episodic aggression (genotype: A0\/A22 or A10\/A22) may already exhibit aggressive, impulsive behaviour. If a dog has two gene copies for episodic aggression (genotype: A22\/A22), extreme behavioural abnormalities can occur.","brand":"FERAGEN","offers":[{"title":"Default Title","offer_id":48146887409987,"sku":"600046","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/EpisodischeAggression.jpg?v=1712140063"},{"product_id":"m-lokus-merle-inkl-basenlange","title":"M locus (merle incl. base length)","description":"Coat pattern: \u003cbr data-mce-fragment=\"1\"\u003eThe typical merle colouring is characterised by a random, patchy lightening of colour, which gives the coat a speckled appearance. Only the areas of the coat that are coloured by eumelanin (black\/brown pigment) are affected. Merle has a dominant effect on these areas. Coat areas coloured with the red pigment phaeomelanin are not affected by merle. A black dog with merle markings is called a blue merle, a brown dog (in the B locus b\/b = brown + brown nose) with merle markings is called a red merle.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eHealth risks:\u003cbr data-mce-fragment=\"1\"\u003eDouble merle dogs that have two genetic predispositions for the merle factor (M\/M) can have severe health problems, such as deafness, blindness, sun intolerance, skin cancer, skeletal deformities, etc.). When breeding with a Merle carrier, it is essential to ensure that a non-Merle (m\/m) dog is chosen for the mating. If two merle dogs are mated, there is a high risk of producing double merle puppies.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eGenetic background:\u003cbr data-mce-fragment=\"1\"\u003eThe merle factor is characterised by a genetic insertion, i.e. an additional gene sequence has been inserted within the affected gene PMEL17. The additional sequence can vary in length from dog to dog. It is assumed that the longer this insertion is, the stronger the merle pattern will be characterised by a more intense lightening.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eIf the dog has a very short insertion variant, it is referred to as cryptic merle or phantom merle (Mc). A dog usually carries this gene variant in a hidden form, with no obvious merle markings or only very small, inconspicuous areas on the body indicating merle. Even dogs that are double cryptic merle (Mc\/Mc) can look inconspicuously like non-merle dogs. Only a genetic test can clarify whether a dog is a Mc carrier. \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eAnother special feature of the Merle insertion is the instability of the additional sequence length. This means that a short Mc variant can become a long Merle variant (M) and vice versa. This must be taken into account especially when mating Merle dogs (M\/m) with optical non-Merle dogs (Mc\/m or Mc\/Mc). In this combination, double merle offspring may be produced if a Mc variant turns into a merle variant (M) in the next generation. Even the M\/Mc genotype (merle\/cryptic merle) can already result in health restrictions. Therefore Mc carriers should only be bred to non merle dogs (m\/m).\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eWhen breeding with merle dogs, it is advisable not to rely on the visual coat pattern. A genetic M-Lokus (Merle) test provides clarification and supports healthy breeding.","brand":"FERAGEN","offers":[{"title":"Default Title","offer_id":48146943607107,"sku":"040007","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/M-Lokus.jpg?v=1712140130"},{"product_id":"pomc-fettleibigkeit-labrador-retriever","title":"POMC - Obesity (Labrador Retriever)","description":"\u003cp\u003ePOMC (proopiomelanocortin) is a gene that codes for a precursor protein that has different functions in different parts of the body, including the brain, where it is involved in regulating appetite and satiety. Mutations in this gene can lead to impaired hunger regulation and obesity.\u003c\/p\u003e\n\u003cp\u003eIn Labrador Retrievers, a specific mutation in the POMC gene has been discovered that is associated with obesity and increased appetite. Dogs with this mutation tend to eat more, are more difficult to get fed and therefore have a higher risk of obesity and associated health problems. This discovery provides important insights into the biological basis of obesity in dogs and may help in the development of strategies to control weight and improve the health and quality of life of obese dogs.\u003c\/p\u003e","brand":"FERAGEN","offers":[{"title":"Default Title","offer_id":48147124453699,"sku":"060120","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0674\/3189\/1218\/files\/POMC.jpg?v=1712140509"}],"url":"https:\/\/shop.feragen.at\/en\/collections\/einzelanalysen.oembed","provider":"FERAGEN Shop","version":"1.0","type":"link"}